Dihydrofluoxymesterone, 5α-Dihydrolevonorgestrel, 5α-Dihydronorethandrolone

Dihydrofluoxymesterone: Dihydrofluoxymesterone shine asrogen da anabolic steroid (AAS) wanda ba'a taɓa tallatar dashi ba. An tantance shi a cikin maganin sankarar mama a cikin mata aƙalla binciken asibiti a cikin shekarun 1970 kuma ya nuna tasiri irin na sauran AAS. Miyagun ƙwayoyi shine haɓakar anaɓaɓɓu na 5a da haɓakar ƙwayar cuta.
5α-Dihydrolevonorgestrel: 5α-Dihydrolevonorgestrel ( 5'-DHLNG ) yana aiki ne na cigaba na progestin levonorgestrel wanda aka kafa ta 5α-reductase. Yana da kusan kashi ɗaya bisa uku na dangantakar levonorgestrel don mai karɓa na progesterone. Ya bambanta da levonorgestrel, gidan yana da aikin haɓaka da aikin antiprogestogenic, sabili da haka yana da mai zaɓaɓɓen mai karɓar mai karɓar progesterone mai kama da aikin. Wannan yayi kama da yanayin norethisterone da 5α-dihydronorethisterone. Baya ga mai karɓar maganin, 5ges-DHLNG yana hulɗa tare da mai karɓar asrogen. Yana da irin wannan kusancin ga mai karɓar nau'ikan asrogen dangane da levonorgestrel, kuma yana da tasirin inrogenic kamar su levonorgestrel da testosterone. 5α-DHLNG ya sake canzawa zuwa 3α, 5α- da 3β, 5α- THLNG , wanda ke da rauni ga mai karɓar estrogen kuma yana da raunin isrogenic mai rauni. Wadannan metabolites ana daukar su da alhakin raunin isrogenic na yawan allurai na levonorgestrel.
5'-Dihydronorethandrolone: 5α-Dihydronorethandrolone ( 5'-DHNED ), wanda aka fi sani da 17α-ethyl-4,5α-dihydro-19-nortestosterone ko kuma 17α-ethyl-5a-estran-17β-ol-3-daya , shine asrogen / anabolic steroid da kuma amintaccen ƙwayar norethandrolone wanda aka kafa ta 5α-reductase. Analogously zuwa nandrolone da 5α-rage metabolite 5α-dihydronandrolone, 5α-DHNED yana nuna raunin kusanci ga mai karɓar inrogene dangane da norethandrolone. Dangantakarsa ga mai karɓar nau'o'in inrogene musamman game da 64% na na norethandrolone.
5α-Dihydrolevonorgestrel: 5α-Dihydrolevonorgestrel ( 5'-DHLNG ) yana aiki ne na cigaba na progestin levonorgestrel wanda aka kafa ta 5α-reductase. Yana da kusan kashi ɗaya bisa uku na dangantakar levonorgestrel don mai karɓa na progesterone. Ya bambanta da levonorgestrel, gidan yana da aikin haɓaka da aikin antiprogestogenic, sabili da haka yana da mai zaɓaɓɓen mai karɓar mai karɓar progesterone mai kama da aikin. Wannan yayi kama da yanayin norethisterone da 5α-dihydronorethisterone. Baya ga mai karɓar maganin, 5ges-DHLNG yana hulɗa tare da mai karɓar asrogen. Yana da irin wannan kusancin ga mai karɓar nau'ikan asrogen dangane da levonorgestrel, kuma yana da tasirin inrogenic kamar su levonorgestrel da testosterone. 5α-DHLNG ya sake canzawa zuwa 3α, 5α- da 3β, 5α- THLNG , wanda ke da rauni ga mai karɓar estrogen kuma yana da raunin isrogenic mai rauni. Wadannan metabolites ana daukar su da alhakin raunin isrogenic na yawan allurai na levonorgestrel.
5α-Dihydroaldosterone: 5α-Dihydroaldosterone shine maye gurbin aldosterone wanda aka kafa ta 5α-reductase. Yana da wakili mai karfi wanda zai iya daidaita shi kamar haka amma ya ɗan bambanta da aldosterone. Ana samar da shi a cikin koda.
5α-Dihydrocorticosterone: 5α-Dihydrocorticosterone , wanda aka fi sani da 11β, 21-dihydroxy-5α-pregnane-3,20-dione , abu ne da ke faruwa a dabi'ance, mummunan kwayar cutar ta glucocorticoid steroid da neurosteroid. An haɓaka shi daga corticosterone ta hanyar enzyme 5a-reductase. DHC yana da tasiri mai raɗaɗi na tsakiya kuma yana lalata tasirin ɗan lokaci cikin dabbobi.
5α-Dihydrocortisol: 5α-Dihydrocortisol ( 5α-DHF ), wanda aka fi sani da hydrallostane ko kuma allodihydrocortisol , wani abu ne na kwayar halitta wanda aka kafa ta 5α-reductase. Yana nan a cikin ruwa mai ban dariya na ido, ana samar da shi a cikin tabarau na ido, kuma yana da hannu wajen tsara samuwar abin raɗaɗi. 5α-DHF za a iya ci gaba da zama cikin 3α, 5α-tetrahydrocortisol ta 3α-hydroxysteroid dehydrogenase.
Dihydrodeoxycorticosterone: 5α-Dihydrodeoxycorticosterone , wanda aka fi sani da 21-hydroxy-5α-juna biyu-20-daya , shine kwayar cutar progestogen da neurosteroid. An hada shi daga adrenal hormone deoxycorticosterone (DOC) ta enzyme 5a-reductase type I. DHDOC wani agonist ne na mai karɓa na progesterone, kazalika da ingantaccen mai gyaran allo na mai karɓar GABA A , kuma an san shi yana da sakamako mai rikitarwa.
5α-Dihydroethisterone: 5α-Dihydroethisterone shine mai amfani da ƙwayoyin cuta na tsohuwar amfani da asibiti amma yanzu an dakatar da progestin ethisterone da gwajin gwaji da kuma rashin cinikin antineoplastic hormonal ethynylandrostanediol (HE-3235). Samuwar ta daga magungunan iyayenta 5aly-reductase ne a cikin kyallen takarda wanda ke bayyana enzyme mai yawan gaske kamar hanta, fata, gashin gashi, da kuma glandan prostate. 5α-DHET yana da mahimmancin kusanci ga masu karɓar maganin hormone na steroid kuma yana iya ba da gudummawa mai mahimmanci ga ayyukan magungunan iyayenta.
5'-Dihydronorethandrolone: 5α-Dihydronorethandrolone ( 5'-DHNED ), wanda aka fi sani da 17α-ethyl-4,5α-dihydro-19-nortestosterone ko kuma 17α-ethyl-5a-estran-17β-ol-3-daya , shine asrogen / anabolic steroid da kuma amintaccen ƙwayar norethandrolone wanda aka kafa ta 5α-reductase. Analogously zuwa nandrolone da 5α-rage metabolite 5α-dihydronandrolone, 5α-DHNED yana nuna raunin kusanci ga mai karɓar inrogene dangane da norethandrolone. Dangantakarsa ga mai karɓar nau'o'in inrogene musamman game da 64% na na norethandrolone.
Dihydrofluoxymesterone: Dihydrofluoxymesterone shine asrogen da anabolic steroid (AAS) wanda ba'a taɓa tallatar dashi ba. An tantance shi a cikin maganin sankarar mama a cikin mata aƙalla binciken asibiti a cikin shekarun 1970 kuma ya nuna tasiri irin na sauran AAS. Miyagun ƙwayoyi shine haɓakar anaɓaɓɓu na 5a da haɓakar ƙwayar cuta.
5α-Dihydrolevonorgestrel: 5α-Dihydrolevonorgestrel ( 5'-DHLNG ) yana aiki ne na cigaba na progestin levonorgestrel wanda aka kafa ta 5α-reductase. Yana da kusan kashi ɗaya bisa uku na dangantakar levonorgestrel don mai karɓa na progesterone. Ya bambanta da levonorgestrel, gidan yana da aikin haɓaka da aikin antiprogestogenic, sabili da haka yana da mai zaɓaɓɓen mai karɓar mai karɓar progesterone mai kama da aikin. Wannan yayi kama da yanayin norethisterone da 5α-dihydronorethisterone. Baya ga mai karɓar maganin, 5ges-DHLNG yana hulɗa tare da mai karɓar asrogen. Yana da irin wannan kusancin ga mai karɓar nau'ikan asrogen dangane da levonorgestrel, kuma yana da tasirin inrogenic kamar su levonorgestrel da testosterone. 5α-DHLNG ya sake canzawa zuwa 3α, 5α- da 3β, 5α- THLNG , wanda ke da rauni ga mai karɓar estrogen kuma yana da raunin isrogenic mai rauni. Wadannan metabolites ana daukar su da alhakin raunin isrogenic na yawan allurai na levonorgestrel.
5α-Dihydronormethandrone: 5α-Dihydronormethandrone , wanda aka fi sani da 17α-methyl-4,5α-dihydro-19-nortestosterone ko kuma kamar 17α-methyl-5a-estran-17β-ol-3-one , shine mai inrogen / anabolic steroid kuma mai yuwuwar maye gurbin normethandrone kafa ta 5α-reductase. Analogously zuwa nandrolone da 5α-rage metabolite 5α-dihydronandrolone, 5α-DHNMT yana nuna raunin kusanci ga mai karɓar inrogene dangane da normethandrone. Dangantakarsa ga mai karɓar nau'o'in inrogene musamman game da 33 zuwa 60% na na normethandrone.
5α-Dihydronormethandrone: 5α-Dihydronormethandrone , wanda aka fi sani da 17α-methyl-4,5α-dihydro-19-nortestosterone ko kuma kamar 17α-methyl-5a-estran-17β-ol-3-one , shine mai inrogen / anabolic steroid kuma mai yuwuwar maye gurbin normethandrone kafa ta 5α-reductase. Analogously zuwa nandrolone da 5α-rage metabolite 5α-dihydronandrolone, 5α-DHNMT yana nuna raunin kusanci ga mai karɓar inrogene dangane da normethandrone. Dangantakarsa ga mai karɓar nau'o'in inrogene musamman game da 33 zuwa 60% na na normethandrone.
5α-Dihydronandrolone: 5α-Dihydronandrolone wani yanayi ne wanda ke faruwa a cikin kwayar cutar anabolic-androgenic (AAS) da kuma rage 5α na nandrolone (19-nortestosterone). Yana da babban maye gurbin nandrolone kuma an samar dashi daga gareshi ta hanyar ayyukan enzyme 5a-reductase kwatankwacin samuwar dihydrotestosterone (DHT) daga testosterone.
5'-Dihydronorethandrolone: 5α-Dihydronorethandrolone ( 5'-DHNED ), wanda aka fi sani da 17α-ethyl-4,5α-dihydro-19-nortestosterone ko kuma 17α-ethyl-5a-estran-17β-ol-3-daya , shine asrogen / anabolic steroid da kuma amintaccen ƙwayar norethandrolone wanda aka kafa ta 5α-reductase. Analogously zuwa nandrolone da 5α-rage metabolite 5α-dihydronandrolone, 5α-DHNED yana nuna raunin kusanci ga mai karɓar inrogene dangane da norethandrolone. Dangantakarsa ga mai karɓar nau'o'in inrogene musamman game da 64% na na norethandrolone.
5'-Dihydronorethisterone: 5α-Dihydronorethisterone shine babban aiki mai narkewa na norethisterone (norethindrone). Norethisterone shine progesin tare da ƙarin ƙarfin inrogenic da estrogenic aiki. 5α-DHNET an ƙirƙira shi daga norethisterone ta 5α-reductase a cikin hanta da sauran kyallen takarda.
5'-Dihydronorethisterone: 5α-Dihydronorethisterone shine babban aiki mai narkewa na norethisterone (norethindrone). Norethisterone shine progesin tare da ƙarin ƙarfin inrogenic da estrogenic aiki. 5α-DHNET an ƙirƙira shi daga norethisterone ta 5α-reductase a cikin hanta da sauran kyallen takarda.
5α-Dihydrolevonorgestrel: 5α-Dihydrolevonorgestrel ( 5'-DHLNG ) yana aiki ne na cigaba na progestin levonorgestrel wanda aka kafa ta 5α-reductase. Yana da kusan kashi ɗaya bisa uku na dangantakar levonorgestrel don mai karɓa na progesterone. Ya bambanta da levonorgestrel, gidan yana da aikin haɓaka da aikin antiprogestogenic, sabili da haka yana da mai zaɓaɓɓen mai karɓar mai karɓar progesterone mai kama da aikin. Wannan yayi kama da yanayin norethisterone da 5α-dihydronorethisterone. Baya ga mai karɓar maganin, 5ges-DHLNG yana hulɗa tare da mai karɓar asrogen. Yana da irin wannan kusancin ga mai karɓar nau'ikan asrogen dangane da levonorgestrel, kuma yana da tasirin inrogenic kamar su levonorgestrel da testosterone. 5α-DHLNG ya sake canzawa zuwa 3α, 5α- da 3β, 5α- THLNG , wanda ke da rauni ga mai karɓar estrogen kuma yana da raunin isrogenic mai rauni. Wadannan metabolites ana daukar su da alhakin raunin isrogenic na yawan allurai na levonorgestrel.
5α-Dihydronormethandrone: 5α-Dihydronormethandrone , wanda aka fi sani da 17α-methyl-4,5α-dihydro-19-nortestosterone ko kuma kamar 17α-methyl-5a-estran-17β-ol-3-one , shine mai inrogen / anabolic steroid kuma mai yuwuwar maye gurbin normethandrone kafa ta 5α-reductase. Analogously zuwa nandrolone da 5α-rage metabolite 5α-dihydronandrolone, 5α-DHNMT yana nuna raunin kusanci ga mai karɓar inrogene dangane da normethandrone. Dangantakarsa ga mai karɓar nau'o'in inrogene musamman game da 33 zuwa 60% na na normethandrone.
5α-Dihydronormethandrone: 5α-Dihydronormethandrone , wanda aka fi sani da 17α-methyl-4,5α-dihydro-19-nortestosterone ko kuma kamar 17α-methyl-5a-estran-17β-ol-3-one , shine mai inrogen / anabolic steroid kuma mai yuwuwar maye gurbin normethandrone kafa ta 5α-reductase. Analogously zuwa nandrolone da 5α-rage metabolite 5α-dihydronandrolone, 5α-DHNMT yana nuna raunin kusanci ga mai karɓar inrogene dangane da normethandrone. Dangantakarsa ga mai karɓar nau'o'in inrogene musamman game da 33 zuwa 60% na na normethandrone.
5α-Dihydroprogesterone: 5α-Dihydroprogesterone shine kwayar cutar da ke cikin kwayar halitta da kuma neurosteroid wanda aka hada daga progesterone. Hakanan matsakaici ne a cikin kira na allopregnanolone da isopregnanolone daga progesterone.
Dihydrotestosterone: Dihydrotestosterone sigar endogenous androgen jima'i steroid da hormone. Enzyme 5a-reductase yana haifar da samuwar DHT daga testosterone a cikin wasu kyallen takarda ciki har da glandon prostate, seminal vesicles, epididymides, fata, follicles gashi, hanta, da kwakwalwa. Wannan enzyme yayi sassauci na C4-5 ninki biyu na testosterone. Dangi ga testosterone, DHT yana da ƙarfi sosai a matsayin mai azabar azabar mai karɓar inrogene (AR).
Dihydrotestosterone undecanoate: Dihydrotestosterone undecanoate ( DHTU ), wanda aka fi sani da androstanolone undecanoate ko stanolone undecanoate , shine maganin inrogene da magungunan asrogen (AAS) wanda ba a taɓa tallatawa ba. Yana da isrogen ester; musamman, shine C17β undecanoate (undecylate) ester na dihydrotestosterone (DHT). DHTU samfuri ne na DHT. Hakanan ga undecanoate na testosterone (TU), DHTU yana aiki da baki. Yana faruwa azaman muhimmin aiki mai narkewa na baka TU. 5a-reductase inhibitor finasteride a haɗe tare da TU na baka ba shi da tasiri a kan canjin farkon wucewar TU zuwa DHTU ko DHT, wataƙila saboda hanya ta musamman ta lymfatic ta sha. Oral DHTU na iya shafan tsarin kwayar halitta irin ta TU, kuma wannan na iya bayyana wadataccen bioavailability.
Dihydrotestosterone undecanoate: Dihydrotestosterone undecanoate ( DHTU ), wanda aka fi sani da androstanolone undecanoate ko stanolone undecanoate , shine maganin inrogene da magungunan asrogen (AAS) wanda ba a taɓa tallatawa ba. Yana da isrogen ester; musamman, shine C17β undecanoate (undecylate) ester na dihydrotestosterone (DHT). DHTU samfuri ne na DHT. Hakanan ga undecanoate na testosterone (TU), DHTU yana aiki da baki. Yana faruwa azaman muhimmin aiki mai narkewa na baka TU. 5a-reductase inhibitor finasteride a haɗe tare da TU na baka ba shi da tasiri a kan canjin farkon wucewar TU zuwa DHTU ko DHT, wataƙila saboda hanya ta musamman ta lymfatic ta sha. Oral DHTU na iya shafan tsarin kwayar halitta irin ta TU, kuma wannan na iya bayyana wadataccen bioavailability.
5α-Dihydronandrolone: 5α-Dihydronandrolone wani yanayi ne wanda ke faruwa a cikin kwayar cutar anabolic-androgenic (AAS) da kuma rage 5α na nandrolone (19-nortestosterone). Yana da babban maye gurbin nandrolone kuma an samar dashi daga gareshi ta hanyar ayyukan enzyme 5a-reductase kwatankwacin samuwar dihydrotestosterone (DHT) daga testosterone.
5α-Dihydrolevonorgestrel: 5α-Dihydrolevonorgestrel ( 5'-DHLNG ) yana aiki ne na cigaba na progestin levonorgestrel wanda aka kafa ta 5α-reductase. Yana da kusan kashi ɗaya bisa uku na dangantakar levonorgestrel don mai karɓa na progesterone. Ya bambanta da levonorgestrel, gidan yana da aikin haɓaka da aikin antiprogestogenic, sabili da haka yana da mai zaɓaɓɓen mai karɓar mai karɓar progesterone mai kama da aikin. Wannan yayi kama da yanayin norethisterone da 5α-dihydronorethisterone. Baya ga mai karɓar maganin, 5ges-DHLNG yana hulɗa tare da mai karɓar asrogen. Yana da irin wannan kusancin ga mai karɓar nau'ikan asrogen dangane da levonorgestrel, kuma yana da tasirin inrogenic kamar su levonorgestrel da testosterone. 5α-DHLNG ya sake canzawa zuwa 3α, 5α- da 3β, 5α- THLNG , wanda ke da rauni ga mai karɓar estrogen kuma yana da raunin isrogenic mai rauni. Wadannan metabolites ana daukar su da alhakin raunin isrogenic na yawan allurai na levonorgestrel.
5α-ciki-17α-ol-3,20-dione: 5α-Ciki-17α-ol-3,20-dione , wanda aka fi sani da 17α-hydroxy-dihydroprogesterone ( 17 ‐ OH-DHP ) shine kwayar cutar ta cikin jiki.
5α-Dihydroprogesterone: 5α-Dihydroprogesterone shine kwayar cutar da ke cikin kwayar halitta da kuma neurosteroid wanda aka hada daga progesterone. Hakanan matsakaici ne a cikin kira na allopregnanolone da isopregnanolone daga progesterone.
Allopregnanediol: Allopregnanediol , ko 5α-pregnane-3α, 20α-diol , shine ingantaccen kwayar halitta na progesterone da allopregnanolone da kuma isomer na pregnanediol (5a-juna biyu-3α, 20a-diol). An samo shi don yin aiki kamar mai rikitarwa mai rikitarwa na rukunin gidan mai karɓar GABA kuma saboda haka yana iya taka rawar gani a matsayin neurosteroid. Hakanan an gano yana aiki azaman azabarcin mai karɓar karɓar karɓar ciki na X, duk da cewa tare da EC 50 wanda ya fi odar girma fiye da na sauran ƙarancin ciki kamar pregnenolone, pregnanediol, allopregnanedione, da allopregnanolone.
Allopregnane: 5α-Ciki , wanda aka fi sani da Allopregnane ko kuma kamar 10β, 13β-dimethyl-17β-ethyl-5 gon-gonane , ita ce mai maganin ƙwaƙwalwa da kuma mahaifa ta mahaɗan kwayoyi masu yawa. Yana daya daga cikin alamun nuna ciki, ɗayan kuma ciki 5β. Abubuwan da aka samo daga Allopregnane sun haɗa da kwayoyin cutar Allopregnanolone, Allopregnanediol, Isopregnanolone, da 5α-Dihydroprogesterone.
5α-Dihydroprogesterone: 5α-Dihydroprogesterone shine kwayar cutar da ke cikin kwayar halitta da kuma neurosteroid wanda aka hada daga progesterone. Hakanan matsakaici ne a cikin kira na allopregnanolone da isopregnanolone daga progesterone.
5α-Ciki-3α, 17α-diol-20-daya: 5α-Pregnane-3α, 17α-diol-20-one , wanda aka fi sani da 17α-hydroxyallopregnanolone ( 17-OH-allo ) shine kwayar cutar mai karfin jini.
Allopregnanediol: Allopregnanediol , ko 5α-pregnane-3α, 20α-diol , shine ingantaccen kwayar halitta na progesterone da allopregnanolone da kuma isomer na pregnanediol (5a-juna biyu-3α, 20a-diol). An samo shi don yin aiki kamar mai rikitarwa mai rikitarwa na rukunin gidan mai karɓar GABA kuma saboda haka yana iya taka rawar gani a matsayin neurosteroid. Hakanan an gano yana aiki azaman azabarcin mai karɓar karɓar karɓar ciki na X, duk da cewa tare da EC 50 wanda ya fi odar girma fiye da na sauran ƙarancin ciki kamar pregnenolone, pregnanediol, allopregnanedione, da allopregnanolone.
Allopregnanediol: Allopregnanediol , ko 5α-pregnane-3α, 20α-diol , shine ingantaccen kwayar halitta na progesterone da allopregnanolone da kuma isomer na pregnanediol (5a-juna biyu-3α, 20a-diol). An samo shi don yin aiki kamar mai rikitarwa mai rikitarwa na rukunin gidan mai karɓar GABA kuma saboda haka yana iya taka rawar gani a matsayin neurosteroid. Hakanan an gano yana aiki azaman azabarcin mai karɓar karɓar karɓar ciki na X, duk da cewa tare da EC 50 wanda ya fi odar girma fiye da na sauran ƙarancin ciki kamar pregnenolone, pregnanediol, allopregnanedione, da allopregnanolone.
5α-Dihydroprogesterone: 5α-Dihydroprogesterone shine kwayar cutar da ke cikin kwayar halitta da kuma neurosteroid wanda aka hada daga progesterone. Hakanan matsakaici ne a cikin kira na allopregnanolone da isopregnanolone daga progesterone.
5α-Rage 5a-reductases , wanda aka fi sani da 3-oxo-5a-steroid 4-dehydrogenases , su ne enzymes da ke cikin maganin metabolism. Suna shiga cikin hanyoyin 3 na rayuwa: bile acid biosynthesis, androgen da estrogen metabolism. Akwai nau'ikan isozymes guda uku na 5a-reductase, SRD5A1, SRD5A2, da SRD5A3, waɗanda suka bambanta a cikin nau'ikan kyallen takarda tare da shekaru.
SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 sigar enzyme ce wacce a cikin mutane ke aiki da kwayar SRD5A2 . Yana ɗayan uku isozymes na 5a-reductase.
5α-Ragectase rashi: 5α-Reductase rashi yanayi ne na rashin daidaituwa wanda zai haifar da maye gurbi a cikin SRD5A2 , kwayar halittar dake shigar enzyme 5a-reductase nau'in 2. Halin da wannan yawanci ke haifarwa shine pseudovaginal perineoscrotal hypospadias , daidaitawar halittar farji na jariri. A wata ma'anar, wannan daidaitawar yana tsakanin tsakiyar halittar al'aurar namiji, da kuma al'aurar mace ta mutum, cikin tsari da bayyana. Yana da wani nau'i na yau da kullun na rashin daidaito na al'ada wanda ya haifar da rashin kulawa da mazajen maza saboda yawancin yanayin tsakanin juna.
SRD5A1: 3-oxo-5α-steroid 4-dehydrogenase 1 sigar enzyme ce wanda ke cikin mutane an sanya shi ta hanyar kwayar SRD5A1 . Yana daya daga cikin nau'i uku na steroid 5a-reductase.
SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 sigar enzyme ce wacce a cikin mutane ke aiki da kwayar SRD5A2 . Yana ɗayan uku isozymes na 5a-reductase.
5α-Ragectase rashi: 5α-Reductase rashi yanayi ne na rashin daidaituwa wanda zai haifar da maye gurbi a cikin SRD5A2 , kwayar halittar dake shigar enzyme 5a-reductase nau'in 2. Halin da wannan yawanci ke haifarwa shine pseudovaginal perineoscrotal hypospadias , daidaitawar halittar farji na jariri. A wata ma'anar, wannan daidaitawar yana tsakanin tsakiyar halittar al'aurar namiji, da kuma al'aurar mace ta mutum, cikin tsari da bayyana. Yana da wani nau'i na yau da kullun na rashin daidaito na al'ada wanda ya haifar da rashin kulawa da mazajen maza saboda yawancin yanayin tsakanin juna.
5α-Ragectase mai hanawa: 5α-Reductase hanawa (5-Aris), kuma aka sani da dihydrotestosterone (DHT) blockers, suna da wani aji na magunguna da antiandrogenic effects wanda ake amfani da farko a lura da kara girman prostate da kuma fatar kan mutum gashi hasara. Hakanan wasu lokuta ana amfani dasu don magance haɓakar gashi mai yawa a cikin mata kuma a matsayin ɓangaren maganin hormone don matan transgender.
5α-Ragectase mai hanawa: 5α-Reductase hanawa (5-Aris), kuma aka sani da dihydrotestosterone (DHT) blockers, suna da wani aji na magunguna da antiandrogenic effects wanda ake amfani da farko a lura da kara girman prostate da kuma fatar kan mutum gashi hasara. Hakanan wasu lokuta ana amfani dasu don magance haɓakar gashi mai yawa a cikin mata kuma a matsayin ɓangaren maganin hormone don matan transgender.
SRD5A1: 3-oxo-5α-steroid 4-dehydrogenase 1 sigar enzyme ce wanda ke cikin mutane an sanya shi ta hanyar kwayar SRD5A1 . Yana daya daga cikin nau'i uku na steroid 5a-reductase.
SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 sigar enzyme ce wacce a cikin mutane ke aiki da kwayar SRD5A2 . Yana ɗayan uku isozymes na 5a-reductase.
5α-Ragectase rashi: 5α-Reductase rashi yanayi ne na rashin daidaituwa wanda zai haifar da maye gurbi a cikin SRD5A2 , kwayar halittar dake shigar enzyme 5a-reductase nau'in 2. Halin da wannan yawanci ke haifarwa shine pseudovaginal perineoscrotal hypospadias , daidaitawar halittar farji na jariri. A wata ma'anar, wannan daidaitawar yana tsakanin tsakiyar halittar al'aurar namiji, da kuma al'aurar mace ta mutum, cikin tsari da bayyana. Yana da wani nau'i na yau da kullun na rashin daidaito na al'ada wanda ya haifar da rashin kulawa da mazajen maza saboda yawancin yanayin tsakanin juna.
SRD5A1: 3-oxo-5α-steroid 4-dehydrogenase 1 sigar enzyme ce wanda ke cikin mutane an sanya shi ta hanyar kwayar SRD5A1 . Yana daya daga cikin nau'i uku na steroid 5a-reductase.
SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 sigar enzyme ce wacce a cikin mutane ke aiki da kwayar SRD5A2 . Yana ɗayan uku isozymes na 5a-reductase.
5α-Ragectase rashi: 5α-Reductase rashi yanayi ne na rashin daidaituwa wanda zai haifar da maye gurbi a cikin SRD5A2 , kwayar halittar dake shigar enzyme 5a-reductase nau'in 2. Halin da wannan yawanci ke haifarwa shine pseudovaginal perineoscrotal hypospadias , daidaitawar halittar farji na jariri. A wata ma'anar, wannan daidaitawar yana tsakanin tsakiyar halittar al'aurar namiji, da kuma al'aurar mace ta mutum, cikin tsari da bayyana. Yana da wani nau'i na yau da kullun na rashin daidaito na al'ada wanda ya haifar da rashin kulawa da mazajen maza saboda yawancin yanayin tsakanin juna.
1-Yanayin zama: 1-Androstenedione , ko 5α-androst-1-ene-3,17-dione , wanda kuma aka sani da 4,5α-dihydro-δ 1 -4-androstenedione , shine asrogen roba da ake kira roba. 5-mai rage isomer ne na kwayar cutar mai karfin 4-androstenedione kuma yana aiki azaman anashan prohormone na 1-testosterone (4,5α-dihydro-δ 1 -testosterone), wanda ya samo asali daga dihydrotestosterone (DHT).
1-Androstenediol: 1-Androstenediol , ko 5α-androst-1-ene-3β, 17β-diol , wanda kuma aka sani da 4,5α-dihydro-δ 1 -4-androstenediol , shi ne prohormone na 1-testosterone (Δ 1 - DHT ).
Androstenol: Androstenol , wanda aka fi sani da 5α-androst-16-en-3α-ol , shine kwayar cututtukan steroidal da neurosteroid a cikin mutane da sauran dabbobi masu shayarwa, musamman aladu. Yana da halayyar kamshi irin na miski.
3β-Androstenol: 3β-Androstenol , wanda aka fi sani da 5α-androst-16-en-3β-ol , wani nau'in kwayar halittar mammalian ne wanda ke faruwa a cikin mutane da aladu. Ana tsammanin yin wasa a cikin warin axillary. An samo shi daga androstenone ta hanyar enzyme 3β-hydroxysteroid dehydrogenase. Ba kamar C3α epimer 3'-androstenol ba, 3'-androstenol ba nuna ƙarfin GABA Mai karɓar mai karɓa ko aiki mai rikitarwa ba.
Androstenone: Androstenone ( 5'-androst-16-en-3-one ) shine pheromone na steroidal. An samo shi a cikin yau, tsirrai na cytoplasm, da naman gwari na truffle. Androstenone shine farkon halittar halittar dabbobi da za a gano. Ana samo shi cikin ɗimbin yawa a cikin jinin aladun maza, kuma, idan aka shaka ta aladen mace wanda yake cikin zafi, hakan yakan haifar da mace da ta ɗauki matsayin kwanciya. Androstenone shine mai aiki a cikin 'Boarmate', samfurin kasuwanci wanda DuPont yayi wanda aka sayarwa manoman alade don gwada shuka don lokacin ƙera ɗan adam.
5α-Androst-2-ene-17-daya: 5α-Androst-2-en-17-one abu ne mai ban mamaki, abin da ke faruwa a yanayi, mai amfani da kwayar cutar asrogen-androgenic steroid (AAS) da kuma abin da ya samo dihydrotestosterone (DHT). Amfani ne na dehydroepiandrosterone (DHEA) a cikin jiki kuma pheromone da ake samu a cikin giwaye da boars. An sayar da 5rost-Androst-2-en-17-one akan Intanet a matsayin "ƙarin abincin abincin". Ya yi kama da <strong> ahoxymethyltestosterone (17α-methyl-5α-androst-2-en-17β-ol) a cikin tsarin sinadarai kuma yana iya yin aiki azaman asrogrogen prohormone.
5α-Androst-2-ene-17-daya: 5α-Androst-2-en-17-one abu ne mai ban mamaki, abin da ke faruwa a yanayi, mai amfani da kwayar cutar asrogen-androgenic steroid (AAS) da kuma abin da ya samo dihydrotestosterone (DHT). Amfani ne na dehydroepiandrosterone (DHEA) a cikin jiki kuma pheromone da ake samu a cikin giwaye da boars. An sayar da 5rost-Androst-2-en-17-one akan Intanet a matsayin "ƙarin abincin abincin". Ya yi kama da <strong> ahoxymethyltestosterone (17α-methyl-5α-androst-2-en-17β-ol) a cikin tsarin sinadarai kuma yana iya yin aiki azaman asrogrogen prohormone.
11-Ketodihydrotestosterone: 11-Ketodihydrotestosterone ( 11-KDHT ), wanda aka fi sani da 5α-androstan-17β-ol-3,11-dione , haƙiƙa ne, wanda ke faruwa a cikin yanayin kwayar halitta da kuma inrogene wanda aka samar da farko, idan ba na musamman ba, a cikin gland adrenal. Yana da alaƙar kusa da 11β-hydroxyandrostenedione (11β-KA4), adrenosterone, da 11-ketotestosterone (11-KT), waɗanda suma ana samar dasu a cikin gland adrenal.
Dihydrotestosterone: Dihydrotestosterone sigar endogenous androgen jima'i steroid da hormone. Enzyme 5a-reductase yana haifar da samuwar DHT daga testosterone a cikin wasu kyallen takarda ciki har da glandon prostate, seminal vesicles, epididymides, fata, follicles gashi, hanta, da kwakwalwa. Wannan enzyme yayi sassauci na C4-5 ninki biyu na testosterone. Dangi ga testosterone, DHT yana da ƙarfi sosai a matsayin mai azabar azabar mai karɓar inrogene (AR).
Androstane: Androstane shine C19 steroid tare da asalin gonane. Androstane na iya kasancewa a matsayin ɗayan isomers biyu, da aka sani da 5α-androstane da 5β-androstane .
3α-Androstanediol: 3α-Androstanediol wanda aka fi sani da 5α-androstane-3α, 17β-diol kuma wani lokacin a gajarta shi a cikin wallafe-wallafen zuwa 3'-diol , shine kwayar cututtukan cututtukan steroid da ƙarancin kwayar cutar da kuma kwayar halittar asrogens kamar dihydrotestosterone (DHT).
3β-Androstanediol: 3β-Androstanediol , wanda aka fi sani da 5α-androstane-3β, 17β-diol , kuma wani lokaci ana taqaitata shi a cikin adabin zuwa 3β-diol , shine kwayar cututtukan hawan steroid da ke cikin kwayar halittar asrogens kamar dehydroepiandrosterone (DHEA) da dihydrotestosterone (DHT).
Androstanediol: Androstanediol na iya koma zuwa: 3α-Androstanediol (5'-androstane-3α, 17β-diol) - ƙarancin neurosteroid, rauni mai ƙarfi androgen da estrogen, kuma matsakaici zuwa androsterone 3β-Androstanediol (5'-androstane-3β, 17'-diol) - isrogen mai haɗari da matsakaici zuwa epiandrosterone 3α-Etiocholanediol - matsakaiciyar matsakaiciya zuwa etiocholanolone 3β-Etiocholanediol - matsakaiciyar matsakaiciya zuwa epietiocholanolone
Karina: Androstanedione , wanda aka fi sani da 5α-androstanedione ko kuma 5α-androstane-3,17-dione , shine kwayar cututtukan asrorono (5a-androstane) da ke faruwa a cikin yanayi da kuma haɗarin kwayar halitta na androgens kamar testosterone, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), da kuma sanyaya ruwa. Cim din C5 ne na etiocholanedione (5'-androstanedione). Androstanedione ya samo asali ne daga 5rost-reductase kuma daga DHT ta hanyar 17β-hydroxysteroid dehydrogenase. Yana da wasu ayyukan inrogenic.
Androstenone: Androstenone ( 5'-androst-16-en-3-one ) shine pheromone na steroidal. An samo shi a cikin yau, tsirrai na cytoplasm, da naman gwari na truffle. Androstenone shine farkon halittar halittar dabbobi da za a gano. Ana samo shi cikin ɗimbin yawa a cikin jinin aladun maza, kuma, idan aka shaka ta aladen mace wanda yake cikin zafi, hakan yakan haifar da mace da ta ɗauki matsayin kwanciya. Androstenone shine mai aiki a cikin 'Boarmate', samfurin kasuwanci wanda DuPont yayi wanda aka sayarwa manoman alade don gwada shuka don lokacin ƙera ɗan adam.
5'-Dihydronorethisterone: 5α-Dihydronorethisterone shine babban aiki mai narkewa na norethisterone (norethindrone). Norethisterone shine progesin tare da ƙarin ƙarfin inrogenic da estrogenic aiki. 5α-DHNET an ƙirƙira shi daga norethisterone ta 5α-reductase a cikin hanta da sauran kyallen takarda.
5α-Dihydroethisterone: 5α-Dihydroethisterone shine mai amfani da ƙwayoyin cuta na tsohuwar amfani da asibiti amma yanzu an dakatar da progestin ethisterone da gwajin gwaji da kuma rashin cinikin antineoplastic hormonal ethynylandrostanediol (HE-3235). Samuwar ta daga magungunan iyayenta 5aly-reductase ne a cikin kyallen takarda wanda ke bayyana enzyme mai yawan gaske kamar hanta, fata, gashin gashi, da kuma glandan prostate. 5α-DHET yana da mahimmancin kusanci ga masu karɓar maganin hormone na steroid kuma yana iya ba da gudummawa mai mahimmanci ga ayyukan magungunan iyayenta.
5'-Dihydronorethisterone: 5α-Dihydronorethisterone shine babban aiki mai narkewa na norethisterone (norethindrone). Norethisterone shine progesin tare da ƙarin ƙarfin inrogenic da estrogenic aiki. 5α-DHNET an ƙirƙira shi daga norethisterone ta 5α-reductase a cikin hanta da sauran kyallen takarda.
5'-Dihydronorethisterone: 5α-Dihydronorethisterone shine babban aiki mai narkewa na norethisterone (norethindrone). Norethisterone shine progesin tare da ƙarin ƙarfin inrogenic da estrogenic aiki. 5α-DHNET an ƙirƙira shi daga norethisterone ta 5α-reductase a cikin hanta da sauran kyallen takarda.
5'-Dihydronorethandrolone: 5α-Dihydronorethandrolone ( 5'-DHNED ), wanda aka fi sani da 17α-ethyl-4,5α-dihydro-19-nortestosterone ko kuma 17α-ethyl-5a-estran-17β-ol-3-daya , shine asrogen / anabolic steroid da kuma amintaccen ƙwayar norethandrolone wanda aka kafa ta 5α-reductase. Analogously zuwa nandrolone da 5α-rage metabolite 5α-dihydronandrolone, 5α-DHNED yana nuna raunin kusanci ga mai karɓar inrogene dangane da norethandrolone. Dangantakarsa ga mai karɓar nau'o'in inrogene musamman game da 64% na na norethandrolone.
Dihydrofluoxymesterone: Dihydrofluoxymesterone shine asrogen da anabolic steroid (AAS) wanda ba'a taɓa tallatar dashi ba. An tantance shi a cikin maganin sankarar mama a cikin mata aƙalla binciken asibiti a cikin shekarun 1970 kuma ya nuna tasiri irin na sauran AAS. Miyagun ƙwayoyi shine haɓakar anaɓaɓɓu na 5a da haɓakar ƙwayar cuta.
5α-Dihydrolevonorgestrel: 5α-Dihydrolevonorgestrel ( 5'-DHLNG ) yana aiki ne na cigaba na progestin levonorgestrel wanda aka kafa ta 5α-reductase. Yana da kusan kashi ɗaya bisa uku na dangantakar levonorgestrel don mai karɓa na progesterone. Ya bambanta da levonorgestrel, gidan yana da aikin haɓaka da aikin antiprogestogenic, sabili da haka yana da mai zaɓaɓɓen mai karɓar mai karɓar progesterone mai kama da aikin. Wannan yayi kama da yanayin norethisterone da 5α-dihydronorethisterone. Baya ga mai karɓar maganin, 5ges-DHLNG yana hulɗa tare da mai karɓar asrogen. Yana da irin wannan kusancin ga mai karɓar nau'ikan asrogen dangane da levonorgestrel, kuma yana da tasirin inrogenic kamar su levonorgestrel da testosterone. 5α-DHLNG ya sake canzawa zuwa 3α, 5α- da 3β, 5α- THLNG , wanda ke da rauni ga mai karɓar estrogen kuma yana da raunin isrogenic mai rauni. Wadannan metabolites ana daukar su da alhakin raunin isrogenic na yawan allurai na levonorgestrel.
5'-Dihydronorethandrolone: 5α-Dihydronorethandrolone ( 5'-DHNED ), wanda aka fi sani da 17α-ethyl-4,5α-dihydro-19-nortestosterone ko kuma 17α-ethyl-5a-estran-17β-ol-3-daya , shine asrogen / anabolic steroid da kuma amintaccen ƙwayar norethandrolone wanda aka kafa ta 5α-reductase. Analogously zuwa nandrolone da 5α-rage metabolite 5α-dihydronandrolone, 5α-DHNED yana nuna raunin kusanci ga mai karɓar inrogene dangane da norethandrolone. Dangantakarsa ga mai karɓar nau'o'in inrogene musamman game da 64% na na norethandrolone.
5α-Dihydrolevonorgestrel: 5α-Dihydrolevonorgestrel ( 5'-DHLNG ) yana aiki ne na cigaba na progestin levonorgestrel wanda aka kafa ta 5α-reductase. Yana da kusan kashi ɗaya bisa uku na dangantakar levonorgestrel don mai karɓa na progesterone. Ya bambanta da levonorgestrel, gidan yana da aikin haɓaka da aikin antiprogestogenic, sabili da haka yana da mai zaɓaɓɓen mai karɓar mai karɓar progesterone mai kama da aikin. Wannan yayi kama da yanayin norethisterone da 5α-dihydronorethisterone. Baya ga mai karɓar maganin, 5ges-DHLNG yana hulɗa tare da mai karɓar asrogen. Yana da irin wannan kusancin ga mai karɓar nau'ikan asrogen dangane da levonorgestrel, kuma yana da tasirin inrogenic kamar su levonorgestrel da testosterone. 5α-DHLNG ya sake canzawa zuwa 3α, 5α- da 3β, 5α- THLNG , wanda ke da rauni ga mai karɓar estrogen kuma yana da raunin isrogenic mai rauni. Wadannan metabolites ana daukar su da alhakin raunin isrogenic na yawan allurai na levonorgestrel.
5α-Dihydroaldosterone: 5α-Dihydroaldosterone shine maye gurbin aldosterone wanda aka kafa ta 5α-reductase. Yana da wakili mai karfi wanda zai iya daidaita shi kamar haka amma ya ɗan bambanta da aldosterone. Ana samar da shi a cikin koda.
5α-Dihydrocorticosterone: 5α-Dihydrocorticosterone , wanda aka fi sani da 11β, 21-dihydroxy-5α-pregnane-3,20-dione , abu ne da ke faruwa a dabi'ance, mummunan kwayar cutar ta glucocorticoid steroid da neurosteroid. An haɓaka shi daga corticosterone ta hanyar enzyme 5a-reductase. DHC yana da tasiri mai raɗaɗi na tsakiya kuma yana lalata tasirin ɗan lokaci cikin dabbobi.
5α-Dihydrocortisol: 5α-Dihydrocortisol ( 5α-DHF ), wanda aka fi sani da hydrallostane ko kuma allodihydrocortisol , wani abu ne na kwayar halitta wanda aka kafa ta 5α-reductase. Yana nan a cikin ruwa mai ban dariya na ido, ana samar da shi a cikin tabarau na ido, kuma yana da hannu wajen tsara samuwar abin raɗaɗi. 5α-DHF za a iya ci gaba da zama cikin 3α, 5α-tetrahydrocortisol ta 3α-hydroxysteroid dehydrogenase.
Dihydrodeoxycorticosterone: 5α-Dihydrodeoxycorticosterone , wanda aka fi sani da 21-hydroxy-5α-juna biyu-20-daya , shine kwayar cutar progestogen da neurosteroid. An hada shi daga adrenal hormone deoxycorticosterone (DOC) ta enzyme 5a-reductase type I. DHDOC wani agonist ne na mai karɓa na progesterone, kazalika da ingantaccen mai gyaran allo na mai karɓar GABA A , kuma an san shi yana da sakamako mai rikitarwa.
5α-Dihydroethisterone: 5α-Dihydroethisterone shine mai amfani da ƙwayoyin cuta na tsohuwar amfani da asibiti amma yanzu an dakatar da progestin ethisterone da gwajin gwaji da kuma rashin cinikin antineoplastic hormonal ethynylandrostanediol (HE-3235). Samuwar ta daga magungunan iyayenta 5aly-reductase ne a cikin kyallen takarda wanda ke bayyana enzyme mai yawan gaske kamar hanta, fata, gashin gashi, da kuma glandan prostate. 5α-DHET yana da mahimmancin kusanci ga masu karɓar maganin hormone na steroid kuma yana iya ba da gudummawa mai mahimmanci ga ayyukan magungunan iyayenta.
5'-Dihydronorethandrolone: 5α-Dihydronorethandrolone ( 5'-DHNED ), wanda aka fi sani da 17α-ethyl-4,5α-dihydro-19-nortestosterone ko kuma 17α-ethyl-5a-estran-17β-ol-3-daya , shine asrogen / anabolic steroid da kuma amintaccen ƙwayar norethandrolone wanda aka kafa ta 5α-reductase. Analogously zuwa nandrolone da 5α-rage metabolite 5α-dihydronandrolone, 5α-DHNED yana nuna raunin kusanci ga mai karɓar inrogene dangane da norethandrolone. Dangantakarsa ga mai karɓar nau'o'in inrogene musamman game da 64% na na norethandrolone.
Dihydrofluoxymesterone: Dihydrofluoxymesterone shine asrogen da anabolic steroid (AAS) wanda ba'a taɓa tallatar dashi ba. An tantance shi a cikin maganin sankarar mama a cikin mata aƙalla binciken asibiti a cikin shekarun 1970 kuma ya nuna tasiri irin na sauran AAS. Miyagun ƙwayoyi shine haɓakar anaɓaɓɓu na 5a da haɓakar ƙwayar cuta.
5α-Dihydrolevonorgestrel: 5α-Dihydrolevonorgestrel ( 5'-DHLNG ) yana aiki ne na cigaba na progestin levonorgestrel wanda aka kafa ta 5α-reductase. Yana da kusan kashi ɗaya bisa uku na dangantakar levonorgestrel don mai karɓa na progesterone. Ya bambanta da levonorgestrel, gidan yana da aikin haɓaka da aikin antiprogestogenic, sabili da haka yana da mai zaɓaɓɓen mai karɓar mai karɓar progesterone mai kama da aikin. Wannan yayi kama da yanayin norethisterone da 5α-dihydronorethisterone. Baya ga mai karɓar maganin, 5ges-DHLNG yana hulɗa tare da mai karɓar asrogen. Yana da irin wannan kusancin ga mai karɓar nau'ikan asrogen dangane da levonorgestrel, kuma yana da tasirin inrogenic kamar su levonorgestrel da testosterone. 5α-DHLNG ya sake canzawa zuwa 3α, 5α- da 3β, 5α- THLNG , wanda ke da rauni ga mai karɓar estrogen kuma yana da raunin isrogenic mai rauni. Wadannan metabolites ana daukar su da alhakin raunin isrogenic na yawan allurai na levonorgestrel.
5α-Dihydronormethandrone: 5α-Dihydronormethandrone , wanda aka fi sani da 17α-methyl-4,5α-dihydro-19-nortestosterone ko kuma kamar 17α-methyl-5a-estran-17β-ol-3-one , shine mai inrogen / anabolic steroid kuma mai yuwuwar maye gurbin normethandrone kafa ta 5α-reductase. Analogously zuwa nandrolone da 5α-rage metabolite 5α-dihydronandrolone, 5α-DHNMT yana nuna raunin kusanci ga mai karɓar inrogene dangane da normethandrone. Dangantakarsa ga mai karɓar nau'o'in inrogene musamman game da 33 zuwa 60% na na normethandrone.
5α-Dihydronormethandrone: 5α-Dihydronormethandrone , wanda aka fi sani da 17α-methyl-4,5α-dihydro-19-nortestosterone ko kuma kamar 17α-methyl-5a-estran-17β-ol-3-one , shine mai inrogen / anabolic steroid kuma mai yuwuwar maye gurbin normethandrone kafa ta 5α-reductase. Analogously zuwa nandrolone da 5α-rage metabolite 5α-dihydronandrolone, 5α-DHNMT yana nuna raunin kusanci ga mai karɓar inrogene dangane da normethandrone. Dangantakarsa ga mai karɓar nau'o'in inrogene musamman game da 33 zuwa 60% na na normethandrone.
5α-Dihydronandrolone: 5α-Dihydronandrolone wani yanayi ne wanda ke faruwa a cikin kwayar cutar anabolic-androgenic (AAS) da kuma rage 5α na nandrolone (19-nortestosterone). Yana da babban maye gurbin nandrolone kuma an samar dashi daga gareshi ta hanyar ayyukan enzyme 5a-reductase kwatankwacin samuwar dihydrotestosterone (DHT) daga testosterone.
5'-Dihydronorethandrolone: 5α-Dihydronorethandrolone ( 5'-DHNED ), wanda aka fi sani da 17α-ethyl-4,5α-dihydro-19-nortestosterone ko kuma 17α-ethyl-5a-estran-17β-ol-3-daya , shine asrogen / anabolic steroid da kuma amintaccen ƙwayar norethandrolone wanda aka kafa ta 5α-reductase. Analogously zuwa nandrolone da 5α-rage metabolite 5α-dihydronandrolone, 5α-DHNED yana nuna raunin kusanci ga mai karɓar inrogene dangane da norethandrolone. Dangantakarsa ga mai karɓar nau'o'in inrogene musamman game da 64% na na norethandrolone.
5'-Dihydronorethisterone: 5α-Dihydronorethisterone shine babban aiki mai narkewa na norethisterone (norethindrone). Norethisterone shine progesin tare da ƙarin ƙarfin inrogenic da estrogenic aiki. 5α-DHNET an ƙirƙira shi daga norethisterone ta 5α-reductase a cikin hanta da sauran kyallen takarda.
5'-Dihydronorethisterone: 5α-Dihydronorethisterone shine babban aiki mai narkewa na norethisterone (norethindrone). Norethisterone shine progesin tare da ƙarin ƙarfin inrogenic da estrogenic aiki. 5α-DHNET an ƙirƙira shi daga norethisterone ta 5α-reductase a cikin hanta da sauran kyallen takarda.
5α-Dihydrolevonorgestrel: 5α-Dihydrolevonorgestrel ( 5'-DHLNG ) yana aiki ne na cigaba na progestin levonorgestrel wanda aka kafa ta 5α-reductase. Yana da kusan kashi ɗaya bisa uku na dangantakar levonorgestrel don mai karɓa na progesterone. Ya bambanta da levonorgestrel, gidan yana da aikin haɓaka da aikin antiprogestogenic, sabili da haka yana da mai zaɓaɓɓen mai karɓar mai karɓar progesterone mai kama da aikin. Wannan yayi kama da yanayin norethisterone da 5α-dihydronorethisterone. Baya ga mai karɓar maganin, 5ges-DHLNG yana hulɗa tare da mai karɓar asrogen. Yana da irin wannan kusancin ga mai karɓar nau'ikan asrogen dangane da levonorgestrel, kuma yana da tasirin inrogenic kamar su levonorgestrel da testosterone. 5α-DHLNG ya sake canzawa zuwa 3α, 5α- da 3β, 5α- THLNG , wanda ke da rauni ga mai karɓar estrogen kuma yana da raunin isrogenic mai rauni. Wadannan metabolites ana daukar su da alhakin raunin isrogenic na yawan allurai na levonorgestrel.
5α-Dihydronormethandrone: 5α-Dihydronormethandrone , wanda aka fi sani da 17α-methyl-4,5α-dihydro-19-nortestosterone ko kuma kamar 17α-methyl-5a-estran-17β-ol-3-one , shine mai inrogen / anabolic steroid kuma mai yuwuwar maye gurbin normethandrone kafa ta 5α-reductase. Analogously zuwa nandrolone da 5α-rage metabolite 5α-dihydronandrolone, 5α-DHNMT yana nuna raunin kusanci ga mai karɓar inrogene dangane da normethandrone. Dangantakarsa ga mai karɓar nau'o'in inrogene musamman game da 33 zuwa 60% na na normethandrone.
5α-Dihydronormethandrone: 5α-Dihydronormethandrone , wanda aka fi sani da 17α-methyl-4,5α-dihydro-19-nortestosterone ko kuma kamar 17α-methyl-5a-estran-17β-ol-3-one , shine mai inrogen / anabolic steroid kuma mai yuwuwar maye gurbin normethandrone kafa ta 5α-reductase. Analogously zuwa nandrolone da 5α-rage metabolite 5α-dihydronandrolone, 5α-DHNMT yana nuna raunin kusanci ga mai karɓar inrogene dangane da normethandrone. Dangantakarsa ga mai karɓar nau'o'in inrogene musamman game da 33 zuwa 60% na na normethandrone.
5α-Dihydroprogesterone: 5α-Dihydroprogesterone shine kwayar cutar da ke cikin kwayar halitta da kuma neurosteroid wanda aka hada daga progesterone. Hakanan matsakaici ne a cikin kira na allopregnanolone da isopregnanolone daga progesterone.
Dihydrotestosterone: Dihydrotestosterone sigar endogenous androgen jima'i steroid da hormone. Enzyme 5a-reductase yana haifar da samuwar DHT daga testosterone a cikin wasu kyallen takarda ciki har da glandon prostate, seminal vesicles, epididymides, fata, follicles gashi, hanta, da kwakwalwa. Wannan enzyme yayi sassauci na C4-5 ninki biyu na testosterone. Dangi ga testosterone, DHT yana da ƙarfi sosai a matsayin mai azabar azabar mai karɓar inrogene (AR).
Dihydrotestosterone undecanoate: Dihydrotestosterone undecanoate ( DHTU ), wanda aka fi sani da androstanolone undecanoate ko stanolone undecanoate , shine maganin inrogene da magungunan asrogen (AAS) wanda ba a taɓa tallatawa ba. Yana da isrogen ester; musamman, shine C17β undecanoate (undecylate) ester na dihydrotestosterone (DHT). DHTU samfuri ne na DHT. Hakanan ga undecanoate na testosterone (TU), DHTU yana aiki da baki. Yana faruwa azaman muhimmin aiki mai narkewa na baka TU. 5a-reductase inhibitor finasteride a haɗe tare da TU na baka ba shi da tasiri a kan canjin farkon wucewar TU zuwa DHTU ko DHT, wataƙila saboda hanya ta musamman ta lymfatic ta sha. Oral DHTU na iya shafan tsarin kwayar halitta irin ta TU, kuma wannan na iya bayyana wadataccen bioavailability.
Dihydrotestosterone undecanoate: Dihydrotestosterone undecanoate ( DHTU ), wanda aka fi sani da androstanolone undecanoate ko stanolone undecanoate , shine maganin inrogene da magungunan asrogen (AAS) wanda ba a taɓa tallatawa ba. Yana da isrogen ester; musamman, shine C17β undecanoate (undecylate) ester na dihydrotestosterone (DHT). DHTU samfuri ne na DHT. Hakanan ga undecanoate na testosterone (TU), DHTU yana aiki da baki. Yana faruwa azaman muhimmin aiki mai narkewa na baka TU. 5a-reductase inhibitor finasteride a haɗe tare da TU na baka ba shi da tasiri a kan canjin farkon wucewar TU zuwa DHTU ko DHT, wataƙila saboda hanya ta musamman ta lymfatic ta sha. Oral DHTU na iya shafan tsarin kwayar halitta irin ta TU, kuma wannan na iya bayyana wadataccen bioavailability.
5α-Dihydronandrolone: 5α-Dihydronandrolone wani yanayi ne wanda ke faruwa a cikin kwayar cutar anabolic-androgenic (AAS) da kuma rage 5α na nandrolone (19-nortestosterone). Yana da babban maye gurbin nandrolone kuma an samar dashi daga gareshi ta hanyar ayyukan enzyme 5a-reductase kwatankwacin samuwar dihydrotestosterone (DHT) daga testosterone.
5α-ciki-17α-ol-3,20-dione: 5α-Ciki-17α-ol-3,20-dione , wanda aka fi sani da 17α-hydroxy-dihydroprogesterone ( 17 ‐ OH-DHP ) shine kwayar cutar ta cikin jiki.
5α-Dihydroprogesterone: 5α-Dihydroprogesterone shine kwayar cutar da ke cikin kwayar halitta da kuma neurosteroid wanda aka hada daga progesterone. Hakanan matsakaici ne a cikin kira na allopregnanolone da isopregnanolone daga progesterone.
Allopregnanediol: Allopregnanediol , ko 5α-pregnane-3α, 20α-diol , shine ingantaccen kwayar halitta na progesterone da allopregnanolone da kuma isomer na pregnanediol (5a-juna biyu-3α, 20a-diol). An samo shi don yin aiki kamar mai rikitarwa mai rikitarwa na rukunin gidan mai karɓar GABA kuma saboda haka yana iya taka rawar gani a matsayin neurosteroid. Hakanan an gano yana aiki azaman azabarcin mai karɓar karɓar karɓar ciki na X, duk da cewa tare da EC 50 wanda ya fi odar girma fiye da na sauran ƙarancin ciki kamar pregnenolone, pregnanediol, allopregnanedione, da allopregnanolone.
Allopregnane: 5α-Ciki , wanda aka fi sani da Allopregnane ko kuma kamar 10β, 13β-dimethyl-17β-ethyl-5 gon-gonane , ita ce mai maganin ƙwaƙwalwa da kuma mahaifa ta mahaɗan kwayoyi masu yawa. Yana daya daga cikin alamun nuna ciki, ɗayan kuma ciki 5β. Abubuwan da aka samo daga Allopregnane sun haɗa da kwayoyin cutar Allopregnanolone, Allopregnanediol, Isopregnanolone, da 5α-Dihydroprogesterone.
5α-Dihydroprogesterone: 5α-Dihydroprogesterone shine kwayar cutar da ke cikin kwayar halitta da kuma neurosteroid wanda aka hada daga progesterone. Hakanan matsakaici ne a cikin kira na allopregnanolone da isopregnanolone daga progesterone.
5α-Ciki-3α, 17α-diol-20-daya: 5α-Pregnane-3α, 17α-diol-20-one , wanda aka fi sani da 17α-hydroxyallopregnanolone ( 17-OH-allo ) shine kwayar cutar mai karfin jini.
Allopregnanediol: Allopregnanediol , ko 5α-pregnane-3α, 20α-diol , shine ingantaccen kwayar halitta na progesterone da allopregnanolone da kuma isomer na pregnanediol (5a-juna biyu-3α, 20a-diol). An samo shi don yin aiki kamar mai rikitarwa mai rikitarwa na rukunin gidan mai karɓar GABA kuma saboda haka yana iya taka rawar gani a matsayin neurosteroid. Hakanan an gano yana aiki azaman azabarcin mai karɓar karɓar karɓar ciki na X, duk da cewa tare da EC 50 wanda ya fi odar girma fiye da na sauran ƙarancin ciki kamar pregnenolone, pregnanediol, allopregnanedione, da allopregnanolone.
Allopregnanediol: Allopregnanediol , ko 5α-pregnane-3α, 20α-diol , shine ingantaccen kwayar halitta na progesterone da allopregnanolone da kuma isomer na pregnanediol (5a-juna biyu-3α, 20a-diol). An samo shi don yin aiki kamar mai rikitarwa mai rikitarwa na rukunin gidan mai karɓar GABA kuma saboda haka yana iya taka rawar gani a matsayin neurosteroid. Hakanan an gano yana aiki azaman azabarcin mai karɓar karɓar karɓar ciki na X, duk da cewa tare da EC 50 wanda ya fi odar girma fiye da na sauran ƙarancin ciki kamar pregnenolone, pregnanediol, allopregnanedione, da allopregnanolone.
5α-Dihydroprogesterone: 5α-Dihydroprogesterone shine kwayar cutar da ke cikin kwayar halitta da kuma neurosteroid wanda aka hada daga progesterone. Hakanan matsakaici ne a cikin kira na allopregnanolone da isopregnanolone daga progesterone.
5α-Rage 5a-reductases , wanda aka fi sani da 3-oxo-5a-steroid 4-dehydrogenases , su ne enzymes da ke cikin maganin metabolism. Suna shiga cikin hanyoyin 3 na rayuwa: bile acid biosynthesis, androgen da estrogen metabolism. Akwai nau'ikan isozymes guda uku na 5a-reductase, SRD5A1, SRD5A2, da SRD5A3, waɗanda suka bambanta a cikin nau'ikan kyallen takarda tare da shekaru.
SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 sigar enzyme ce wacce a cikin mutane ke aiki da kwayar SRD5A2 . Yana ɗayan uku isozymes na 5a-reductase.
SRD5A1: 3-oxo-5α-steroid 4-dehydrogenase 1 sigar enzyme ce wanda ke cikin mutane an sanya shi ta hanyar kwayar SRD5A1 . Yana daya daga cikin nau'i uku na steroid 5a-reductase.
SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 sigar enzyme ce wacce a cikin mutane ke aiki da kwayar SRD5A2 . Yana ɗayan uku isozymes na 5a-reductase.
5α-Ragectase rashi: 5α-Reductase rashi yanayi ne na rashin daidaituwa wanda zai haifar da maye gurbi a cikin SRD5A2 , kwayar halittar dake shigar enzyme 5a-reductase nau'in 2. Halin da wannan yawanci ke haifarwa shine pseudovaginal perineoscrotal hypospadias , daidaitawar halittar farji na jariri. A wata ma'anar, wannan daidaitawar yana tsakanin tsakiyar halittar al'aurar namiji, da kuma al'aurar mace ta mutum, cikin tsari da bayyana. Yana da wani nau'i na yau da kullun na rashin daidaito na al'ada wanda ya haifar da rashin kulawa da mazajen maza saboda yawancin yanayin tsakanin juna.
5α-Ragectase mai hanawa: 5α-Reductase hanawa (5-Aris), kuma aka sani da dihydrotestosterone (DHT) blockers, suna da wani aji na magunguna da antiandrogenic effects wanda ake amfani da farko a lura da kara girman prostate da kuma fatar kan mutum gashi hasara. Hakanan wasu lokuta ana amfani dasu don magance haɓakar gashi mai yawa a cikin mata kuma a matsayin ɓangaren maganin hormone don matan transgender.
5α-Ragectase mai hanawa: 5α-Reductase hanawa (5-Aris), kuma aka sani da dihydrotestosterone (DHT) blockers, suna da wani aji na magunguna da antiandrogenic effects wanda ake amfani da farko a lura da kara girman prostate da kuma fatar kan mutum gashi hasara. Hakanan wasu lokuta ana amfani dasu don magance haɓakar gashi mai yawa a cikin mata kuma a matsayin ɓangaren maganin hormone don matan transgender.
SRD5A1: 3-oxo-5α-steroid 4-dehydrogenase 1 sigar enzyme ce wanda ke cikin mutane an sanya shi ta hanyar kwayar SRD5A1 . Yana daya daga cikin nau'i uku na steroid 5a-reductase.
SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 sigar enzyme ce wacce a cikin mutane ke aiki da kwayar SRD5A2 . Yana ɗayan uku isozymes na 5a-reductase.
5α-Ragectase rashi: 5α-Reductase rashi yanayi ne na rashin daidaituwa wanda zai haifar da maye gurbi a cikin SRD5A2 , kwayar halittar dake shigar enzyme 5a-reductase nau'in 2. Halin da wannan yawanci ke haifarwa shine pseudovaginal perineoscrotal hypospadias , daidaitawar halittar farji na jariri. A wata ma'anar, wannan daidaitawar yana tsakanin tsakiyar halittar al'aurar namiji, da kuma al'aurar mace ta mutum, cikin tsari da bayyana. Yana da wani nau'i na yau da kullun na rashin daidaito na al'ada wanda ya haifar da rashin kulawa da mazajen maza saboda yawancin yanayin tsakanin juna.
SRD5A1: 3-oxo-5α-steroid 4-dehydrogenase 1 sigar enzyme ce wanda ke cikin mutane an sanya shi ta hanyar kwayar SRD5A1 . Yana daya daga cikin nau'i uku na steroid 5a-reductase.
SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 sigar enzyme ce wacce a cikin mutane ke aiki da kwayar SRD5A2 . Yana ɗayan uku isozymes na 5a-reductase.
5α-Ragectase rashi: 5α-Reductase rashi yanayi ne na rashin daidaituwa wanda zai haifar da maye gurbi a cikin SRD5A2 , kwayar halittar dake shigar enzyme 5a-reductase nau'in 2. Halin da wannan yawanci ke haifarwa shine pseudovaginal perineoscrotal hypospadias , daidaitawar halittar farji na jariri. A wata ma'anar, wannan daidaitawar yana tsakanin tsakiyar halittar al'aurar namiji, da kuma al'aurar mace ta mutum, cikin tsari da bayyana. Yana da wani nau'i na yau da kullun na rashin daidaito na al'ada wanda ya haifar da rashin kulawa da mazajen maza saboda yawancin yanayin tsakanin juna.
SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 sigar enzyme ce wacce a cikin mutane ke aiki da kwayar SRD5A2 . Yana ɗayan uku isozymes na 5a-reductase.
SRD5A1: 3-oxo-5α-steroid 4-dehydrogenase 1 sigar enzyme ce wanda ke cikin mutane an sanya shi ta hanyar kwayar SRD5A1 . Yana daya daga cikin nau'i uku na steroid 5a-reductase.
SRD5A2: 3-oxo-5α-steroid 4-dehydrogenase 2 sigar enzyme ce wacce a cikin mutane ke aiki da kwayar SRD5A2 . Yana ɗayan uku isozymes na 5a-reductase.